GITR / Tnfrsf18 (Mouse)(DTA-1) , 0.2mg / mL

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily , also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation , proliferation , cytokine production as well as MAPKs and NF-B activation , and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.