KPNA1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : IMA5_HUMAN antibody; Importin alpha 1 subunit antibody; Importin alpha 5 antibody; Importin alpha S1 antibody; Importin subunit alpha-5; N-terminally processed antibody; IPO A5 antibody; IPOA 5 antibody; IPOA5 antibody; Karyopherin alpha 1 antibody; Karyopherin alpha 1 subunit antibody; Karyopherin subunit alpha-1 antibody; KPNA 1 antibody; KPNA1 antibody; mSRP 1 antibody; mSRP1 antibody; NPI 1 antibody; NPI-1 antibody; NPI1 antibody; Nucleoprotein interactor 1 antibody; RAG cohort protein 2 antibody; RCH 2 antibody; RCH2 antibody; Recombination activating gene cohort 2 antibody; SRP 1 antibody; SRP1 beta antibody; SRP1-beta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P52294
Immunogen : Recombinant Human Importin subunit alpha-5 protein (8-538AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 thro µgh binding to nucleoporin FxFG repeats and the complex is subsequently translocated thro µgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is tho µght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus µL84 by recognizing a non-classical NLS.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KPNA1
Research Areas : Immunology; Signal transduction