IRAK1BP1 Antibody

Volume : 50 µL
Clone Number :
Aliases : ActA binding protein 3 antibody; AIP70 antibody; IKBP1_HUMAN antibody; Interleukin 1 receptor associated kinase 1 binding protein 1 antibody; Interleukin-1 receptor-associated kinase 1-binding protein 1 antibody; IRAK1-binding protein 1 antibody; IRAK1BP1 antibody; Signaling molec µLe that associates with Pelle-like kinase antibody; SIMPL antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q5VVH5
Immunogen : Fusion protein of Human IRAK1BP1
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB, IHC; ELISA : 1 : 2000-1 : 5000, WB : 1 : 500-1 : 2000, IHC : 1 : 50-1 : 200
Background : SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be f µLly active.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen affinity purification
Conj µgate : Non-conj µgated
Buffer : -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IRAK1BP1
Research Areas : Immunology;Signal transduction