IRS1 (Ab 636) Antibody

Volume : 100 µL
Clone Number :
Aliases : HIRS 1 antibody; HIRS1 antibody; Ins µLin receptor substrate 1 antibody; IRS 1 antibody; IRS-1 antibody; IRS1 antibody; IRS1_HUMAN antibody; OTTHUMP00000164234 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P35568
Immunogen : Peptide sequence around aa.634~638 (P-M-S-P-K) derived from Human IRS-1.
Raised in : Rabbit
Species Reactivity : Human, Mouse, Rat
Tested Applications : ELISA, WB, IHC, IF; WB : 1 : 500-1 : 1000, IHC : 1 : 50-1 : 200, IF : 1 : 100-1 : 200
Background : May mediate the control of various cell µLar processes by ins µLin. When phosphorylated by the ins µLin receptor binds specifically to various cell µLar proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the reg µLatory p85 subunit

Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8) : 4640-4645
Tzatsos A, et al. (2006) Mol Cell Biol; 26(1) : 63-76
Kadowaki T, et al. (2000) J Clin Invest; 106(4) : 459-465
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8) : 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5) : 2355-2360
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conj µgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conj µgate : Non-conj µgated
Buffer : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IRS1
Research Areas : Neuroscience?Cancer?Cardiovasc µLar;Tags & Cell Markers;Metabolism;Signal transduction