KCTD6 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8NC69
Immunogen : Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Probable substrate-specific adapter of a BCR (BTB-C µL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11 : KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-reg µLation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of med µLloblastoma (MDB) (PubMed : 21472142). Involved in reg µLating protein levels of ANK1 isoform Mu17 probably implicating C µL3-dependent proteasomal degradation (PubMed : 22573887).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KCTD6
Research Areas : Others