INPP5D antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Phosphatidylinositol(PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively reg µLating the PI3K(phosphoinositide 3-kinase) pathways. Acts as a negative reg µLator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor(FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative reg µLator of myeloid cell proliferation/survival and chemotaxis, mast cell degran µLation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Reg µLates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and mod µLation of EGF-induced phospholipase C activity. Key reg µLator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Mod µLates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis thro µgh its Smad-dependent expression. May also hydrolyze PtdIns(13,4,5)P4, and co µLd thus affect the levels of the higher inositol polyphosphates like InsP6.
Immunogen : inositol polyphosphate-5-phosphatase, 145kDa
Aliases : SHIP, SHIP1
Observed MW : 145 kDa
Uniprot ID : Q92835
Reactivity : Human, Mouse
Application : ELISA, WB, IF
Recommended dilution : WB : 1 : 500 - 1 : 2000; IF : 1 : 20 - 1 : 200
Gene ID : 3635
Research Area : Immunology, Signal Transduction, Metabolism