LGR4 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins(RSPO1 RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracell µLar Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin(NDP), such res µLts however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritub µLar myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a reg µLator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative reg µLator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in reg µLating the circadian rhythms of plasma lipids, partially thro µgh reg µLating the rhythmic expression of MTTP(By similarity).
Immunogen : leucine-rich repeat-containing G protein-coupled receptor 4
Aliases :
Observed MW :
Uniprot ID : Q9BXB1
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC
Recommended dilution : IHC : 1 : 20-1 : 200
Gene ID : 55366
Research Area : Signal Transduction