Volume : 50 µg
Clone Number :
Aliases : Alk antibody; ALK tyrosine kinase receptor antibody; ALK/EML4 fusion gene; included antibody; ALK/NPM1 fusion gene; included antibody; ALK_HUMAN antibody; anaplastic lymphoma kinase (Ki-1) antibody; Anaplastic lymphoma kinase antibody; Anaplastic lymphoma kinase Ki1 antibody; anaplastic lymphoma receptor tyrosine kinase antibody; CD 246 antibody; CD246 antibody; CD246 antigen antibody; EC 2.7.10.1 antibody; Ki 1 antibody; Ki1 antibody; mutant anaplastic lymphoma kinase antibody; NBLST 3 antibody; NBLST3 antibody; Tcrz antibody; TFG/ALK antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UM73
Immunogen : Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, thro µgh specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1 as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and reg µLation of cell proliferation. MDK-binding induces phosphorylation of the ALK target ins µLin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, res µLting also in cell proliferation induction. Drives NF-kappa-B activation, probably thro µgh IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALK
Research Areas : Neuroscience; Cancer; Tags & Cell Markers