Alpha B Crystallin antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Alpha B-crystallin, encoded by CRYAB gene, is m µLtifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms(SNPs) in the promoter region of CRYAB gene have been associated with in m µLtiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a m µLtisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Immunogen : crystallin, alpha B
Aliases : Alpha B Crystallin, Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component
Observed MW : 20 kDa
Uniprot ID : P02511
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC, IP
Recommended dilution : WB : 1 : 500-1 : 5000; IHC : 1 : 20-1 : 200; IP : 1 : 200-1 : 2000
Gene ID :
Research Area : Neuroscience, Cancer, Metabolism