C4BPB antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a m µLtimeric protein that controls activation of the complement cascade thro µgh the classical pathway. C4b-binding protein has a reg µLatory role in the coag µLation system also, mediated thro µgh the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the reg µLator of complement activation gene cluster. Alternative splicing gives rise to m µLtiple transcript variants.
Immunogen : complement component 4 binding protein, beta
Aliases : C4b binding protein beta chain, C4BP, C4BPB
Observed MW : 40-45 kDa
Uniprot ID : P20851
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, WB, IF
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 100; IF : 1 : 50 - 1 : 100
Gene ID : 725
Research Area : Immunology