Neurofilament , phospho (NF-H) (Neuronal Marker)(NE14) , CF647 conjugate , 0.1mg / mL

This MAb reacts with a 200 kDa protein , identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase , this Ab no longer binds. Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons , peripheral nerves , and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L) , 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural , neuroendocrine , and endocrine tumors. Neuromas , ganglioneuromas , gangliogliomas , ganglioneuroblastomas , and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids , neuroendocrine carcinomas of the skin , and oat cell carcinomas of the lung also express neurofilament.