OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136) , CF647 conjugate , 0.1mg / mL

Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites , regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells , mantle B-cells , monocytoid B-cells , and plasma cells show high level expression of Oct-2. Additionally , mantle cell lymphoma , follicular lymphoma , marginal zone lymphoma , plasmacytoma , Burkitt lymphoma , diffuse large cell lymphoma , diffuse large B-cell lymphoma , Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B , T-cell , myelomonocytic , and epithelial cell lines , whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells , it is believed that this factor participates in transcriptional regulation during T-cell activation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.