Myofibroblast Marker(PR 2D3) , 0.2mg / mL

Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis , inflammation , repair , wound contraction and fibrosis. Like smooth muscle (SM) cells , myofibroblasts contain microfilament bundles and express -SM Actin , the Actin isoform that is present in myoepithelial cells and SM cells and especially abundant in vascular SM cells. Myofibroblasts secrete inflammatory and anti-inflammatory cytokines , chemokines , growth factors and lipid and gaseous inflammatory mediators , as well as extracellular matrix proteins and proteases in most organs and tissues. Besides being temporarily present following tissue injuries and fibrocontractive diseases , myofibroblasts are also present under normal conditions in regions such as the skin , pulmonary septa and periodontal ligaments. Stem cell factor and platelet-derived growth factor (PDGF) are two secreted proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.