OX40 / CD134/ TNFRSF4 (Immuno-Oncology Target)(OX40/3108) , 0.2mg / mL

ThisMAb recognizes a protein of 43 kDa , identified as OX40 , which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes , hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation , proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation , especially in case of multiple sclerosis and psoriatic lesions. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.