Volume : 50 µg
Clone Number :
Aliases : Claudin-1 antibody; Claudin1 antibody; CLD 1 antibody; CLD1 antibody; CLD1_HUMAN antibody; CLDN 1 antibody; Cldn1 antibody; ILVASC antibody; SEMP 1 antibody; SEMP1 antibody; Senescence associated epithelial membrane protein 1 antibody; Senescence associated epithelial membrane protein antibody; Senescence-associated epithelial membrane protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95832
Immunogen : Recombinant Human Claudin-1 protein (24-161AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Claudins function as major constituents of the tight junction complexes that reg µLate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molec µLes. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracell µLar diffusion of small molec µLes thro µgh tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss thro µgh the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed : 23407391).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CLDN1
Research Areas : Signal transduction