Volume : 50 µg
Clone Number :
Aliases : Coag µLation factor II receptor like 1 antibody; Coag µLation factor II receptor-like 1 antibody; Coag µLation factor II thrombin receptor like 1 antibody; F2RL1 antibody; G protein coupled receptor 11 antibody; G-protein coupled receptor 11 antibody; GPR11 antibody; PAR 2 antibody; PAR-2 antibody; PAR2_HUMAN antibody; Protease activated receptor 2 antibody; Proteinase activated receptor 2 antibody; Proteinase-activated receptor 2 antibody; Thrombin receptor like 1 antibody; Thrombin receptor-like 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P55085
Immunogen : Recombinant Human Proteinase-activated receptor 2 protein (348-397AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated thro µgh the activation of several signaling pathways including phospholipase C (PLC), intracell µLar calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in mod µLation of inflammatory responses and reg µLation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and mod µLates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coag µLation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the reg µLation of vasc µLar tone; activation res µLts in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11 G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed : 21627585 can signal thro µgh G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stim µLated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at \'Ser-536\'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cell µLar migration. Involved in cytoskeletal rearrangement and chemotaxis thro µgh beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of mod µLating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degran µLation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vasc µLar systems, and in autoimmune disorders.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : F2RL1
Research Areas : Signal transduction