Volume : 50 µg
Clone Number :
Aliases : HOME1_HUMAN antibody; Homer antibody; HOMER 1A antibody; HOMER 1B antibody; HOMER 1C antibody; Homer homolog 1 (Drosophila) antibody; homer homolog 1 antibody; Homer protein homolog 1 antibody; homer scaffolding protein 1 antibody; Homer; Drosophila; homolog of; 1 antibody; Homer; neuronal immediate early gene; 1 antibody; Homer-1 antibody; Homer1 antibody; HOMER1A antibody; HOMER1B antibody; HOMER1C antibody; SYN47 antibody; Ves 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q86YM7
Immunogen : Recombinant Human Homer protein homolog 1 protein (1-354AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1 GRM5, ITPR1 DNM3, RYR1 RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracell µLar calcium release. May also couple GRM1 to PI3 kinase thro µgh its interaction with AGAP2. Isoform 1 reg µLates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to reg µLate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1 which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HOMER1
Research Areas : Neuroscience