Volume : 50 µg
Clone Number :
Aliases : Adenosine 5' monophosphoramidase antibody; Adenosine 5''-monophosphoramidase antibody; HINT 1 antibody; HINT1 antibody; HINT1_HUMAN antibody; Histidine triad nucleotide binding protein 1 antibody; Histidine triad nucleotide-binding protein 1 antibody; PKCI 1 antibody; PKCI-1 antibody; PKCI1 antibody; PRKCNH1 antibody; Protein kinase C inhibitor 1 antibody; Protein kinase C interacting protein 1 antibody; Protein kinase C-interacting protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P49773
Immunogen : Recombinant Human Histidine triad nucleotide-binding protein 1 protein (2-126AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5\'monophosphoramidate (AMP-NH2), adenosine 5\'monophosphomorpholidate (AMP-morpholidate) and guanosine 5\'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5\'-O-phosphorothioate and guanosine 5\'-O-phosphorothioate to the corresponding nucleoside 5\'-O-phosphates with concomitant release of hydrogen s µLfide. In addition, functions as scaffolding protein that mod µLates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Mod µLates p53/TP53 levels and p53/TP53-mediated apoptosis. Mod µLates proteasomal degradation of target proteins by the SCF (SKP2-C µL1-F-box protein) E3 ubiquitin-protein ligase complex.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HINT1
Research Areas : Epigenetics and Nuclear Signaling; Cancer