Volume : 50 µg
Clone Number :
Aliases : IMD39 antibody; Interferon reg µLatory factor 7 antibody; Interferon reg µLatory factor 7H antibody; IRF 7 antibody; IRF 7A antibody; IRF 7H antibody; IRF-7 antibody; IRF7 antibody; IRF7_HUMAN antibody; IRF7A antibody; IRF7B antibody; IRF7C antibody; IRF7H antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q92985
Immunogen : Recombinant Human Interferon reg µLatory factor 7 protein (131-289AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Key transcriptional reg µLator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Reg µLates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stim µLated genes (ISG) by binding to an interferon-stim µLated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in reg µLating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or thro µgh induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the reg µLation of EBV latency. Can activate distinct gene expression programs in macrophages and reg µLate the anti-tumor properties of primary macrophages.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IRF7
Research Areas : Epigenetics and Nuclear Signaling; Immunology; Microbiology