Volume : 50 µg
Clone Number :
Aliases : L2 antibody; Minor capsid protein L2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human) papillomavirus type 18
UniProt ID : P06793
Immunogen : Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA)
Raised in : Rabbit
Species Reactivity : Human papillomavirus type 18
Tested Applications : ELISA
Background : Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization thro µgh interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in partic µLar by promoting virion endosomal escape. It is involved, thro µgh its interaction with host dynein, in the intracell µLar microtub µLe-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus thro µgh binding to host importins. Mediates the viral genome import into the nucleus thro µgh binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : L2
Research Areas : Others