Volume : 50 µg
Clone Number :
Aliases : ASP antibody; C3 and PZP-like alpha-2-macroglob µLin domain-containing protein 1 antibody; C3 antibody; C3adesArg antibody; C3bc antibody; CO3_HUMAN antibody; Complement C3c alpha'' chain fragment 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01024
Immunogen : Recombinant Human Complement C3 protein (26-225AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.30 Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vasc µLar permeability and causes histamine release from mast cells and basophilic leukocytes. Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.30 Acylation stim µLating protein (ASP) : adipogenic hormone that stim µLates triglyceride (TG) synthesis and glucose transport in adipocytes, reg µLating fat storage and playing a role in postprandial TG clearance. Appears to stim µLate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for GPR77. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of GPR77.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : C3
Research Areas : Neuroscience; Immunology