Volume : 50 µg
Clone Number :
Aliases : Apoptotic cysteine protease antibody; Apoptotic protease Mch 5 antibody; C/EBP alpha antibody; C/ebpalpha antibody; CAP4 antibody; Caspase 8 precursor antibody; CBF-A antibody; CCAAT Enhancer Binding Protein alpha antibody; CCAAT/enhancer binding protein (C/EBP); alpha antibody; CCAAT/enhancer-binding protein alpha antibody; CEBP antibody; CEBP A antibody; CEBP alpha antibody; Cebpa antibody; CEBPA_HUMAN antibody; FADD homologous ICE/CED 3 like protease antibody; FADD like ICE antibody; FLICE antibody; ICE like apoptotic protease 5 antibody; ICE8 antibody; MACH antibody; MCH5 antibody; MORT1 associated CED 3 homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P49715
Immunogen : Recombinant Human CCAAT/enhancer-binding protein alpha protein (1-124AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5\'-T[TG]NNGNAA[TG]-3\' acting as an activator on distinct target genes (PubMed : 11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to gran µLocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To reg µLate these different processes at the proper moment and tissue, interplays with other transcription factors and mod µLators. Downreg µLates the expression of genes that maintain cells in an undifferentiated and proliferative state thro µgh E2F1 repression, which is critical for its ability to induce adipocyte and gran µLocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed : 14660596). In liver, reg µLates gluconeogenesis and lipogenesis thro µgh different mechanisms. To reg µLate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and reg µLating the expression of target genes such as PCK1 or G6PC. To mod µLate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter thro µgh FOXO1 binding sites (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CEBPA
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cardiovasc µLar; Metabolism; Signal transduction
