Volume : 50 µg
Clone Number :
Aliases : CSF1R antibody; FMS antibody; Macrophage colony-stim µLating factor 1 receptor antibody; CSF-1 receptor antibody; CSF-1-R antibody; CSF-1R antibody; M-CSF-R antibody; EC 2.7.10.1 antibody; Proto-oncogene c-Fms antibody; CD antigen CD115 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Felis catus (Cat) (Felis silvestris catus)
UniProt ID : P13369
Immunogen : Recombinant Felis silvestris catus Macrophage colony-stim µLating factor 1 receptor protein (20-514AA)
Raised in : Rabbit
Species Reactivity : Felis silvestris catus
Tested Applications :
Background : Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the reg µLation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1 and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the reg µLation of osteoclast proliferation and differentiation, the reg µLation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, reg µLates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1 PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cell µLar signaling molec µLes diacylglycerol and inositol 14,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1 the reg µLatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1 and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracell µLar domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-reg µLated by protein phosphatases, such as INPP5D/SHIP-1 that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSF1R
Research Areas : Others
