Volume : 50 µg
Clone Number :
Aliases : FFA3R antibody; Ffar3 antibody; FFAR3_HUMAN antibody; Free fatty acid receptor 3 antibody; G protein coupled receptor 41 antibody; G-protein coupled receptor 41 antibody; gpcr41 antibody; GPR41 antibody; gpr42 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O14843
Immunogen : Recombinant Human Free fatty acid receptor 3 protein (280-346AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the reg µLation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molec µLes. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation res µLts in the formation of inositol 14,5-trisphosphate, the mobilization of intracell µLar calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracell µLar cAMP accum µLation (PubMed : 12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and mod µLates the activity of sympathetic neurons thro µgh a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may reg µLate energy expenditure thro µgh the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accum µLating in the intestine, it may also signal to the brain via neural circuits which in turn wo µLd reg µLate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, reg µLate blood pressure thro µgh renin secretion. May also reg µLate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly reg µLate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, reg µLating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed : 12496283, PubMed : 12711604).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : FFAR3
Research Areas : Cardiovasc µLar; Metabolism
