Volume : 50 µL
Clone Number :
Aliases : HAP 1 antibody; HAP 1A antibody; HAP 2 antibody; HAP-1 antibody; Hap1 antibody; HAP1_HUMAN antibody; HAP2 antibody; HAPP antibody; hHAP1 antibody; hHLP1 antibody; HIP 5 antibody; HIP5 antibody; HLP antibody; HLP1 antibody; Huntingtin associated protein 1A antibody; Huntingtin-associated protein 1 antibody; huntingtin-associated protein 2 antibody; Neuroan 1 antibody; Neuroan1 antibody; OTTHUMP00000164746 antibody; OTTHUMP00000164747 antibody; OTTHUMP00000232821 antibody; OTTHUMP00000232822 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P54257
Immunogen : Recombinant Human Huntingtin-associated protein 1 protein (328-580AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracell µLar trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesic µLar transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesic µLar transport function via association with microtub µLe-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in reg µLation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in reg µLation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others s µggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in reg µLation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HAP1
Research Areas : Neuroscience; Signal transduction
