Volume : 50 µg
Clone Number :
Aliases : 10 kDa chaperonin antibody; 10 kDa heat shock protein mitochondrial antibody; 10 kDa heat shock protein; mitochondrial antibody; CH10_HUMAN antibody; Chaperonin 10 antibody; Chaperonin 10 homolog antibody; CPN10 antibody; cpn10 homolog antibody; Early pregnancy factor antibody; Early-pregnancy factor antibody; EPF antibody; GROES antibody; GroES homolog antibody; Heat shock 10kD protein 1 chaperonin 10 antibody; Heat shock 10kDa protein 1 antibody; Heat shock 10kDa protein 1 chaperonin 10 antibody; Heat shock protein family E (Hsp10) member antibody; Heat-shock 10-kD protein antibody; Hsp10 antibody; Hspe1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P61604
Immunogen : Recombinant Human 10 kDa heat shock protein, mitochondrial protein (2-102AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Co-chaperonin implicated in mitochondrial protein import and macromolec µLar assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed : 7912672, PubMed : 1346131 PubMed : 11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits res µLts in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HSPE1
Research Areas : Cancer; Metabolism; Signal transduction