Volume : 50 µg
Clone Number :
Aliases : CD314 antibody; CD314 antigen antibody; D12S2489E antibody; Killer cell lectin like receptor subfamily K member 1 antibody; Killer cell lectin-like receptor subfamily K member 1 antibody; KLR antibody; KLRC4 KLRK1 readthro µgh antibody; KLRK1 antibody; NK cell receptor D antibody; NK lectin-like receptor antibody; NKG2 D activating NK receptor antibody; NKG2 D type II integral membrane protein antibody; NKG2-D antibody; NKG2-D type II integral membrane protein antibody; NKG2-D-activating NK receptor antibody; Nkg2d antibody; NKG2D_HUMAN antibody; NKLLR antibody; NKR P2 antibody; Nkrp2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P26718
Immunogen : Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Function as an activating and costim µLatory receptor involved in immunosurveillance upon binding to various cell µLar stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stim µLatory and costim µLatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costim µLatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stim µLates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, c µLminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a reg µLatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, µLBP1 µLBP2, µLBP3 ( µLBP2> µLBP1> µLBP3) and µLBP4.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KLRK1
Research Areas : Immunology