Volume : 50 µg
Clone Number :
Aliases : 5031439C20 antibody; AI326300 antibody; EDG 2 antibody; EDG2 antibody; Endothelial differentiation gene 2 antibody; Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2 antibody; GPCR 26 antibody; Gpcr26 antibody; Gpcr91 antibody; GPR26 antibody; Kdt2 antibody; LPA 1 antibody; LPA receptor 1 antibody; LPA receptor EDG2 antibody; LPA-1 antibody; lpA1 antibody; Lpar1 antibody; LPAR1_HUMAN antibody; Lysophosphatidic acid receptor 1 antibody; Lysophosphatidic acid receptor Edg-2 antibody; Lysophosphatidic acid receptor EDG2 antibody; MGC105279 antibody; MGC29102 antibody; Mrec1.3 antibody; rec.1.3 antibody; Ventric µLar zone gene 1 antibody; vzg-1 antibody; VZG1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q92633
Immunogen : Recombinant Human Lysophosphatidic acid receptor 1 protein (316-364AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for lysophosphatidic acid (LPA) (PubMed : 9070858, PubMed : 19306925, PubMed : 25025571 PubMed : 26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cell µLar cAMP levels (PubMed : 26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed : 19656035, PubMed : 19733258, PubMed : 26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 14,5-trisphosphate (PubMed : 19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the reg µLation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed : 26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed : 26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Thro µgh its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed : 18066075, PubMed : 19656035, PubMed : 19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the ad µLt dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LPAR1
Research Areas : Cardiovasc µLar; Metabolism; Signal transduction