Volume : 50 µg
Clone Number :
Aliases : CATSPER2 antibody; Cation channel sperm-associated protein 2 antibody; CatSper2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96P56
Immunogen : Recombinant Human Cation channel sperm-associated protein 2 protein (5-112AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successf µL fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracell µLar progesterone and prostaglandins following the sequence : progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracell µLar pH.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CATSPER2
Research Areas : Others