CBL Antibody HRP conjugated
Volume : 50 µg
Clone Number :
Aliases : 4732447J05Rik antibody; C CBL antibody; Cas Br M (murine) ecotropic retroviral transforming sequence antibody; Casitas B lineage lymphoma proto oncogene antibody; Casitas B-lineage lymphoma proto-oncogene antibody; CBL 2 antibody; cbl antibody; CBL_HUMAN antibody; CBL2 antibody; E3 ubiquitin protein ligase CBL antibody; E3 ubiquitin-protein ligase CBL antibody; Oncogene CBL2 antibody; Proto oncogene c CBL antibody; Proto-oncogene c-CBL antibody; RGD1561386 antibody; RING finger protein 55 antibody; RNF55 antibody; Signal transduction protein CBL antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P22681
Immunogen : Recombinant Human E3 ubiquitin-protein ligase CBL protein (548-847AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Adapter protein that functions as a negative reg µLator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conj µgating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1 FGFR1 FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the reg µLation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The \'Tyr-731\' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CBL
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction