INSIG1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : CL 6 antibody; CL6 antibody; INSI1_HUMAN antibody; INSIG 1 antibody; INSIG 1 membrane protein antibody; INSIG-1 antibody; insig1 antibody; INSIG1 membrane protein antibody; Ins µLin induced gene 1 antibody; Ins µLin induced gene 1 protein antibody; Ins µLin-induced gene 1 protein antibody; MGC1405 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15503
Immunogen : Recombinant Human Ins µLin-induced gene 1 protein (1-87AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol reg µLatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic retic µLum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a reg µLatory role during G0/G1 transition of cell growth.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : INSIG1
Research Areas : Cancer; Cardiovasc µLar; Metabolism; Signal transduction