INVS Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : INVS antibody; INV antibody; NPHP2 antibody; Inversin antibody; Inversion of embryo turning homolog antibody; Nephrocystin-2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y283
Immunogen : Recombinant Human Inversin protein (1-101AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for normal renal development and establishment of left-right axis. Probably acts as a molec µLar switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This s µggests that it is required in renal development to oppose the repression of terminal differentiation of tub µLar epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1 NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : INVS
Research Areas : Signal transduction; Stem cells