IPO13 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Imp 13 antibody; Imp13 antibody; Importin-13 antibody; Importin13 antibody; IPO 13 antibody; Ipo13 antibody; IPO13_HUMAN antibody; Kap 13 antibody; Kap13 antibody; Karyopherin 13 antibody; Karyopherin-13 antibody; Karyopherin13 antibody; KIAA0274 antibody; Late gestation lung 2 antibody; Late gestation lung 2 protein antibody; Lgl2 antibody; Ran binding protein 13 antibody; Ran-binding protein 13 antibody; RanBP 13 antibody; RanBP13 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O94829
Immunogen : Recombinant Human Importin-13 protein (501-700AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is tho µght to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) thro µgh binding to nucleoporin and the complex is subsequently translocated thro µgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is tho µght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IPO13
Research Areas : Others