KCNAB1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : hKvb3 antibody; hKvBeta3 antibody; K(+) channel subunit beta-1 antibody; KCAB1_HUMAN antibody; KCNA1B antibody; KCNAB1 antibody; Kv-beta-1 antibody; Kvb1.3 antibody; Voltage-gated potassium channel beta-1 subunit antibody; Voltage-gated potassium channel subunit beta-1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14722
Immunogen : Recombinant Human Voltage-gated potassium channel subunit beta-1 protein (287-401AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Cytoplasmic potassium channel subunit that mod µLates the characteristics of the channel-forming alpha-subunits (PubMed : 7499366, PubMed : 7603988, PubMed : 17156368,PubMed : 17540341 PubMed : 19713757). Mod µLates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed : 9763623). Promotes the closure of KCNA1 KCNA2 and KCNA5 channels (PubMed : 7499366, PubMed : 7890032, PubMed : 7603988, PubMed : 7649300, PubMed : 8938711 PubMed : 12077175, PubMed : 12130714, PubMed : 15361858, PubMed : 17540341 PubMed : 19713757). Accelerates KCNA4 channel closure (PubMed : 7890032, PubMed : 7649300, PubMed : 7890764, PubMed : 9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed : 17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1 KCNA2 or KCNB1 (PubMed : 7890032, PubMed : 7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-reg µLation of potassium channel activity (PubMed : 17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KCNAB1
Research Areas : Neuroscience