KIDINS220 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : Ankyrin repeat-rich membrane-spanning protein antibody; arms antibody; KDIS_HUMAN antibody; kidins220 antibody; Kinase D interacting substance of 220 kDa antibody; Kinase D-interacting substrate of 220 kDa antibody; rgd 619949 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9 µLH0
Immunogen : Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Promotes a prolonged MAP-kinase signaling by neurotrophins thro µgh activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, res µLting in Rap1-dependent sustained ERK activation. May play an important role in reg µLating postsynaptic signal transduction thro µgh the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Mod µLates stress-induced apoptosis of melanoma cells via reg µLation of the MEK/ERK signaling pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KIDINS220
Research Areas : Neuroscience; Cardiovasc µLar; Signal transduction