KRIT1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : Ankyrin repeat containing protein Krit1 antibody; CAM antibody; CCM 1 antibody; CCM1 antibody; Cerebral cavernous malformations 1 antibody; Cerebral cavernous malformations 1 protein antibody; Krev interaction trapped 1 antibody; Krev interaction trapped protein 1 antibody; KRIT 1 antibody; KRIT1 ankyrin repeat containing antibody; KRIT1 antibody; KRIT1_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O00522
Immunogen : Recombinant Human Krev interaction trapped protein 1 protein (471-585AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Component of the CCM signaling pathway which is a crucial reg µLator of heart and vessel formation and integrity (By similarity). Negative reg µLator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly thro µgh activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vasc µLar lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtub µLe-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracell µLar reactive oxygen species (ROS) homeostasis to prevent oxidative cell µLar damage. Reg µLates the homeostasis of intracell µLar ROS thro µgh an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-reg µLation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accum µLation of intracell µLar ROS thro µgh the mod µLation of FOXO1 and SOD2 levels.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KRIT1
Research Areas : Neuroscience; Cardiovasc µLar; Signal transduction