LATS1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : h-warts antibody; Large tumor suppressor homolog 1 antibody; LATS large tumor suppressor homolog 1 antibody; LATS1 antibody; LATS1_HUMAN antibody; Serine threonine protein kinase LATS1 antibody; Serine/threonine-protein kinase LATS1 antibody; WARTS antibody; WARTS protein kinase antibody; wts antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95835
Immunogen : Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Negative reg µLator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ Volume control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1 in complex with its reg µLatory protein SAV1 phosphorylates and activates LATS1/2 in complex with its reg µLatory protein MOB1 which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to reg µLate cell µLar genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy thro µgh its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively reg µLates G2/M transition by down-reg µLating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by reg µLating actin polymerization thro µgh negative mod µLation of LIMK1. May also play a role in endocrine function.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LATS1
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction