KIT Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : C Kit antibody; c-Kit antibody; c-Kit Ligand antibody; CD117 antibody; Kit antibody; Kit Ligand antibody; KIT oncogene antibody; KIT proto oncogene receptor tyrosine kinase antibody; KIT_HUMAN antibody; Mast cell growth factor receptor antibody; Mast/stem cell growth factor receptor Kit antibody; MGF antibody; p145 c-kit antibody; PBT antibody; Piebald trait protein antibody; Proto oncogene c Kit antibody; Proto oncogene tyrosine protein kinase Kit antibody; Proto-oncogene c-Kit antibody; SCF Receptor antibody; SCFR antibody; soluble KIT variant 1 antibody; Steel Factor Receptor antibody; Stem cell factor receptor antibody; tyrosine protein kinase Kit antibody; Tyrosine-protein kinase Kit antibody; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog antibody; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein antibody; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P10721
Immunogen : Recombinant Human Mast/stem cell growth factor receptor Kit protein (73-195AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the reg µLation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1 PLCG1 SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1 the reg µLatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1 STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cell µLar signaling molec µLes diacylglycerol and inositol 14,5-trisphosphate. KIT signaling is mod µLated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1 STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1 CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1 PLCG1 SRC and SHC1.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KIT
Research Areas : Neuroscience; Cancer; Developmental biology; Tags & Cell Markers; Immunology; Signal transduction; Stem cells