KANK1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : ANKRD 15 antibody; Ankyrin repeat domain 15 antibody; Ankyrin repeat domain containing protein 15 antibody; Ankyrin repeat domain-containing protein 15 antibody; DKFZp451G231 antibody; KANK antibody; KANK1 antibody; KANK1_HUMAN antibody; KIAA0172 antibody; Kidney ankyrin repeat containing protein antibody; Kidney ankyrin repeat-containing protein antibody; KN motif and ankyrin repeat domain-containing protein 1 antibody; MGC43128 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14678
Immunogen : Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 protein (66-255AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Involved in the control of cytoskeleton formation by reg µLating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation thro µgh PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KANK1
Research Areas : Cancer;Signal transduction