KCNC3 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Kcnc3 antibody; KCNC3_HUMAN antibody; KSHIIID antibody; KV3.3 antibody; Potassium voltage gated channel Shaw related subfamily member 3 antibody; Potassium voltage gated channel subfamily C member 3 antibody; Potassium voltage-gated channel subfamily C member 3 antibody; SCA13 antibody; Shaw related subfamily, member 3 antibody; Shaw related voltage gated potassium channel protein 3 antibody; Spinocerebellar ataxia 13 antibody; Voltage gated potassium channel protein KV3.3 antibody; Voltage gated potassium channel subunit Kv3.3 antibody; Voltage-gated potassium channel subunit Kv3.3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14003
Immunogen : Recombinant Human Potassium voltage-gated channel subfamily C member 3 protein (638-745AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel thro µgh which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed : 10712820, PubMed : 26997484, PubMed : 22289912, PubMed : 23734863, PubMed : 16501573, PubMed : 19953606, PubMed : 21479265, PubMed : 25756792). It plays a role in the reg µLation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in reg µLating the duration and frequency of action potentials that in turn reg µLate the activity of voltage-gated Ca(2+) channels and cell µLar Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed : 23734863, PubMed : 16501573, PubMed : 19953606, PubMed : 21479265, PubMed : 25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed : 26997484).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KCNC3
Research Areas : Neuroscience