KISS1 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : KISS 1 antibody; KiSS 1 metastasis suppressor antibody; Kiss1 antibody; KISS1_HUMAN antibody; Kisspeptin 1 antibody; Kisspeptin 10 antibody; Kisspeptin 13 antibody; Kisspeptin 14 antibody; Kisspeptin antibody; Kisspeptin-1 antibody; Kisspeptin-10 antibody; Kisspeptin-54 antibody; Kisspeptin1 antibody; Malignant melanoma metastasis suppressor antibody; Metastasis suppressor KiSS 1 antibody; Metastasis suppressor KiSS1 antibody; Metastin antibody; MGC39258 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15726
Immunogen : Recombinant Human Metastasis-suppressor KiSS-1 protein (20-138AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Metastasis suppressor protein in malignant melanomas and in some breast cancers. May reg µLate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracell µLar Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine reg µLator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central reg µLation of the gonadotropic axis at puberty and in ad µLthood.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : KISS1
Research Areas : Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology