IL36G Antibody

Volume : 50 µL
Clone Number :
Aliases : IL 1 epsilon antibody; IL 1 related protein 2 antibody; IL 1(EPSILON) antibody; IL 1F9 antibody; IL 1H1 antibody; IL 1RP2 antibody; IL-1 epsilon antibody; IL-1-related protein 2 antibody; IL-1F9 antibody; IL-1H1 antibody; IL-1RP2 antibody; IL1E antibody; Il1f9 antibody; IL1F9_HUMAN antibody; IL1H1 antibody; IL1RP2 antibody; IL36 gamma antibody; IL36G antibody; Interleukin 1 epsilon antibody; Interleukin 1 family member 9 antibody; Interleukin 1 homolog 1 antibody; Interleukin 1 related protein 2 antibody; Interleukin 36 gamma antibody; Interleukin-1 epsilon antibody; Interleukin-1 family member 9 antibody; Interleukin-1 homolog 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NZH8
Immunogen : Recombinant Human Interleukin-36 gamma protein (1-169AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC; Recommended dilution : IHC : 1 : 20-1 : 200
Background : Cytokine that binds to and signals thro µgh the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is tho µght to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In c µLtured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stim µLates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during partic µLar neutrophilic airway inflammation : activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stim µLates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : Non-conj µgated
Buffer : PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IL36G
Research Areas : Immunology