IPO11 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : Imp11 antibody; Importin 11 antibody; Importin-11 antibody; IPO11 antibody; IPO11_HUMAN antibody; Ran binding protein 11 antibody; Ran-binding protein 11 antibody; RanBP11 antibody; SLRN antibody; Synleurin antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UI26
Immunogen : Recombinant Human Importin-11 protein (1-270AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is tho µght to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) thro µgh binding to nucleoporin and the complex is subsequently translocated thro µgh the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is tho µght to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IPO11
Research Areas : Signal transduction