IRF3 (Ab 396) Antibody

Volume : 100 µL
Clone Number :
Aliases : interferon reg µLatory factor 3
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14653
Immunogen : Peptide sequence around aa.394-398(H-I-S-N-S) derived from Human IRF-3.
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, WB; WB : 1 : 500-1 : 1000
Background : Key transcriptional reg µLator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Reg µLates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stim µLated genes (ISG) by binding to an interferon-stim µLated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Affinity purification
Conj µgate : Non-conj µgated
Buffer : Purified Rabbit polyclonal Ab in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IRF3
Research Areas : Epigenetics and Nuclear Signaling;Immunology