Volume : 50 µg
Clone Number :
Aliases : Birc5 antibody; Api4 antibody; Iap4Bac µLoviral IAP repeat-containing protein 5 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; TIAP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : O70201
Immunogen : Recombinant Mouse Bac µLoviral IAP repeat-containing protein 5 protein (1-140AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications : ELISA
Background : M µLtitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important reg µLator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtub µLes. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molec µLe TPX2 to microtub µLes. May counteract a defa µLt induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Birc5
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Birc5 antibody; Api4 antibody; Iap4Bac µLoviral IAP repeat-containing protein 5 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; TIAP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : O70201
Immunogen : Recombinant Mouse Bac µLoviral IAP repeat-containing protein 5 protein (1-140AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications :
Background : M µLtitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important reg µLator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtub µLes. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molec µLe TPX2 to microtub µLes. May counteract a defa µLt induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Birc5
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Birc5 antibody; Api4 antibody; Iap4Bac µLoviral IAP repeat-containing protein 5 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; TIAP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : O70201
Immunogen : Recombinant Mouse Bac µLoviral IAP repeat-containing protein 5 protein (1-140AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications : ELISA
Background : M µLtitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important reg µLator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtub µLes. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molec µLe TPX2 to microtub µLes. May counteract a defa µLt induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Birc5
Research Areas : Others

Volume : 50 µL
Clone Number :
Aliases : API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; Bac µLoviral IAP repeat containing 5 antibody; Bac µLoviral IAP repeat containing protein 5 antibody; Bac µLoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15392
Immunogen : Human SURVIVIN
Raised in : Rabbit
Species Reactivity : Human, Mouse, Rat
Tested Applications : ELISA, WB, IHC
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : Non-conj µgated
Buffer : PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC5
Research Areas : Neuroscience?Cancer;Cell biology

Volume : 50 µg
Clone Number :
Aliases : AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; Bac µLoviral IAP repeat containing 3 antibody; Bac µLoviral IAP repeat containing protein 3 antibody; Bac µLoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_HUMAN antibody; C IAP2 antibody; C-IAP2 antibody; Cell µLar inhibitor of apoptosis 2 antibody; cell µLar inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13489
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 3 protein (76-245AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1 and BCL10. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC3
Research Areas : Cancer; Cell biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; Bac µLoviral IAP repeat containing 3 antibody; Bac µLoviral IAP repeat containing protein 3 antibody; Bac µLoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_HUMAN antibody; C IAP2 antibody; C-IAP2 antibody; Cell µLar inhibitor of apoptosis 2 antibody; cell µLar inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13489
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 3 protein (76-245AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1 and BCL10. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC3
Research Areas : Cancer; Cell biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : AIP 1 antibody; AIP1 antibody; API 2 antibody; API2 antibody; Apoptosis inhibitor 2 antibody; Bac µLoviral IAP repeat containing 3 antibody; Bac µLoviral IAP repeat containing protein 3 antibody; Bac µLoviral IAP repeat-containing protein 3 antibody; BIRC 3 antibody; BIRC3 antibody; BIRC3_HUMAN antibody; C IAP2 antibody; C-IAP2 antibody; Cell µLar inhibitor of apoptosis 2 antibody; cell µLar inhibitor of apoptosis protein 2 antibody; CIAP 2 antibody; CIAP2 antibody; HAIP 1 antibody; HAIP1 antibody; HIAP 1 antibody; HIAP-1 antibody; HIAP1 antibody; IAP homolog C antibody; IAP-1 antibody; Inhibitor of apoptosis protein 1 antibody; MALT 2 antibody; MALT2 antibody; Mammalian IAP homolog C antibody; MIHC antibody; RING finger protein 49 antibody; RNF49 antibody; TNFR2 TRAF signaling complex protein 1 antibody; TNFR2 TRAF signalling complex protein antibody; TNFR2-TRAF-signaling complex protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13489
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 3 protein (76-245AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1 and BCL10. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC3
Research Areas : Cancer; Cell biology; Metabolism

Volume : 100 µL
Host : Rabbit
Clonality : polyclonal Ab
Isotype : IgG
GeneName : BIRC3
GeneID : 330
Uniprot : Q13489
Specificity : BIRC3 Antibody detects endogenous levels of total BIRC3.
Immunogen : A syntheVolumed peptide derived from human BIRC3, corresponding to a region within N-terminal amino acids.
Storage : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Reactivity : Human
Prediction : Sheep
Application : WB,IHC,IF/ICC,ELISA(peptide)
Dilution : WB 1 : 1000-3000, IF/ICC 1 : 100-1 : 500, IHC 1 : 50-1 : 200, ELISA(peptide) 1 : 20000-1 : 40000
Conj µgate : Unconj µgated
RRID : AB_2841111
An Introduction to Blocking Peptides : A superior strategy for validation of antibody binding is the use of blocking peptides. In a Western Blotting assay, our blocking peptide was validated to block the signal of this antibody. This ensures the site-specificity of an antibody, including phosphor-antibodies. In the case of the phosphor- antibodies, the antibodies can and will only recognize the phosphorylated target protein at the corresponding site, not the non-phosphorylated target protein or target protein phosphorylated at a different site.
Cat# Blocking Peptide : DF7625-BP
Des# Blocking Peptide : BIRC3 Blocking peptide
Blocking Peptide Price : $549 CAD

Volume : 50 µg
Clone Number :
Aliases : API 1 antibody; API1 antibody; Apoptosis inhibitor 1 antibody; Bac µLoviral IAP repeat containing 2 antibody; Bac µLoviral IAP repeat containing protein 2 antibody; Bac µLoviral IAP repeat-containing protein 2 antibody; BIRC 2 antibody; BIRC2 antibody; BIRC2_HUMAN antibody; C IAP1 antibody; C-IAP1 antibody; Cell µLar inhibitor of apoptosis 1 antibody; cell µLar inhibitor of apoptosis protein 1 antibody; cIAP 1 antibody; cIAP1 antibody; HIAP 2 antibody; HIAP-2 antibody; HIAP2 antibody; IAP 2 antibody; IAP homolog B antibody; IAP-2 antibody; IAP2 antibody; Inhibitor of apoptosis protein 2 antibody; MIHB antibody; NFR2 TRAF signalling complex protein antibody; RING finger protein 48 antibody; RNF 48 antibody; RNF48 antibody; TNFR2 TRAF signaling complex protein 2 antibody; TNFR2-TRAF-signaling complex protein 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13490
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 2 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1 IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conj µgation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stim µLate the transcriptional activity of E2F1. Plays a role in the mod µLation of the cell cycle.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC2
Research Areas : Cancer; Cell biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : API 1 antibody; API1 antibody; Apoptosis inhibitor 1 antibody; Bac µLoviral IAP repeat containing 2 antibody; Bac µLoviral IAP repeat containing protein 2 antibody; Bac µLoviral IAP repeat-containing protein 2 antibody; BIRC 2 antibody; BIRC2 antibody; BIRC2_HUMAN antibody; C IAP1 antibody; C-IAP1 antibody; Cell µLar inhibitor of apoptosis 1 antibody; cell µLar inhibitor of apoptosis protein 1 antibody; cIAP 1 antibody; cIAP1 antibody; HIAP 2 antibody; HIAP-2 antibody; HIAP2 antibody; IAP 2 antibody; IAP homolog B antibody; IAP-2 antibody; IAP2 antibody; Inhibitor of apoptosis protein 2 antibody; MIHB antibody; NFR2 TRAF signalling complex protein antibody; RING finger protein 48 antibody; RNF 48 antibody; RNF48 antibody; TNFR2 TRAF signaling complex protein 2 antibody; TNFR2-TRAF-signaling complex protein 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13490
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 2 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1 IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conj µgation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stim µLate the transcriptional activity of E2F1. Plays a role in the mod µLation of the cell cycle.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC2
Research Areas : Cancer; Cell biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : API 1 antibody; API1 antibody; Apoptosis inhibitor 1 antibody; Bac µLoviral IAP repeat containing 2 antibody; Bac µLoviral IAP repeat containing protein 2 antibody; Bac µLoviral IAP repeat-containing protein 2 antibody; BIRC 2 antibody; BIRC2 antibody; BIRC2_HUMAN antibody; C IAP1 antibody; C-IAP1 antibody; Cell µLar inhibitor of apoptosis 1 antibody; cell µLar inhibitor of apoptosis protein 1 antibody; cIAP 1 antibody; cIAP1 antibody; HIAP 2 antibody; HIAP-2 antibody; HIAP2 antibody; IAP 2 antibody; IAP homolog B antibody; IAP-2 antibody; IAP2 antibody; Inhibitor of apoptosis protein 2 antibody; MIHB antibody; NFR2 TRAF signalling complex protein antibody; RING finger protein 48 antibody; RNF 48 antibody; RNF48 antibody; TNFR2 TRAF signaling complex protein 2 antibody; TNFR2-TRAF-signaling complex protein 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13490
Immunogen : Recombinant Human Bac µLoviral IAP repeat-containing protein 2 protein (1-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : M µLti-functional protein which reg µLates not only caspases and apoptosis, but also mod µLates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase reg µLating NF-kappa-B signaling and reg µLates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions : acts as a positive reg µLator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include : RIPK1 RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1 IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conj µgation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important reg µLator of innate immune signaling via reg µLation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large m µLti-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stim µLate the transcriptional activity of E2F1. Plays a role in the mod µLation of the cell cycle.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BIRC2
Research Areas : Cancer; Cell biology; Metabolism