Volume : 50 µg
Clone Number :
Aliases : Beta homolg of S. cerevisiae BUB 1 antibody; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody; BUB 1B antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody; Bub1A antibody; BUB1B antibody; BUB1B_HUMAN antibody; BUB1beta antibody; BUBR1 antibody; Budding Uninhibited by Benzimidazoles 1 beta antibody; Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody; hBUBR1 antibody; MAD3/BUB1 related protein kinase antibody; MAD3/BUB1-related protein kinase antibody; MAD3L antibody; Mitotic checkpoint gene BUB1B antibody; Mitotic checkpoint kinase MAD3L antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 beta antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antibody; MVA1 antibody; OTTHUMP00000160319 antibody; Protein SSK1 antibody; SSK 1 antibody; SSK1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O60566
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively reg µLates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1B
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : Beta homolg of S. cerevisiae BUB 1 antibody; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody; BUB 1B antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody; Bub1A antibody; BUB1B antibody; BUB1B_HUMAN antibody; BUB1beta antibody; BUBR1 antibody; Budding Uninhibited by Benzimidazoles 1 beta antibody; Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody; hBUBR1 antibody; MAD3/BUB1 related protein kinase antibody; MAD3/BUB1-related protein kinase antibody; MAD3L antibody; Mitotic checkpoint gene BUB1B antibody; Mitotic checkpoint kinase MAD3L antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 beta antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antibody; MVA1 antibody; OTTHUMP00000160319 antibody; Protein SSK1 antibody; SSK 1 antibody; SSK1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O60566
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively reg µLates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1B
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : Beta homolg of S. cerevisiae BUB 1 antibody; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody; BUB 1B antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody; Bub1A antibody; BUB1B antibody; BUB1B_HUMAN antibody; BUB1beta antibody; BUBR1 antibody; Budding Uninhibited by Benzimidazoles 1 beta antibody; Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody; hBUBR1 antibody; MAD3/BUB1 related protein kinase antibody; MAD3/BUB1-related protein kinase antibody; MAD3L antibody; Mitotic checkpoint gene BUB1B antibody; Mitotic checkpoint kinase MAD3L antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 beta antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antibody; MVA1 antibody; OTTHUMP00000160319 antibody; Protein SSK1 antibody; SSK 1 antibody; SSK1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O60566
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively reg µLates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1B
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology

Volume : 100 µL
Host : Rabbit
Clonality : polyclonal Ab
Isotype : IgG
GeneName : BUB1B
GeneID : 701
Uniprot : O60566
Specificity : BUB1B Antibody detects endogenous levels of total BUB1B.
Immunogen : A syntheVolumed peptide derived from human BUB1B, corresponding to a region within C-terminal amino acids.
Storage : Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reactivity : Human,Mouse,Rat
Prediction : Pig,Bovine,Horse,Sheep,Rabbit,Dog
Application : WB,ELISA(peptide)
Dilution : WB 1 : 500-1 : 2000, ELISA(peptide) 1 : 20000-1 : 40000
Conj µgate : Unconj µgated
RRID : AB_2839863
An Introduction to Blocking Peptides : A superior strategy for validation of antibody binding is the use of blocking peptides. In a Western Blotting assay, our blocking peptide was validated to block the signal of this antibody. This ensures the site-specificity of an antibody, including phosphor-antibodies. In the case of the phosphor- antibodies, the antibodies can and will only recognize the phosphorylated target protein at the corresponding site, not the non-phosphorylated target protein or target protein phosphorylated at a different site.
Cat# Blocking Peptide : DF2657-BP
Des# Blocking Peptide : BUB1B Blocking peptide
Blocking Peptide Price : $549 CAD

Volume : 50 µg
Clone Number :
Aliases : Bub1 antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) antibody; BUB1 mitotic checkpoint serine/threonine kinase antibody; BUB1; S. cerevisiae; homolog of antibody; BUB1_HUMAN antibody; BUB1A antibody; BUB1L antibody; Budding uninhibited by benzimidazoles 1 (yeast homolog) antibody; Budding uninhibited by benzimidazoles 1 homolog antibody; Budding uninhibited by benzimidazoles 1; S. cerevisiae; homolog of antibody; hBUB1 antibody; Homolog of mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 antibody; Mitotic spindle checkpoint kinase antibody; Putative serine/threonine protein kinase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O43683
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 protein (256-577AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine-protein kinase that performs 2 crucial functions during mitosis : it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can reg µLate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1
Research Areas : Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : Bub1 antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) antibody; BUB1 mitotic checkpoint serine/threonine kinase antibody; BUB1; S. cerevisiae; homolog of antibody; BUB1_HUMAN antibody; BUB1A antibody; BUB1L antibody; Budding uninhibited by benzimidazoles 1 (yeast homolog) antibody; Budding uninhibited by benzimidazoles 1 homolog antibody; Budding uninhibited by benzimidazoles 1; S. cerevisiae; homolog of antibody; hBUB1 antibody; Homolog of mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 antibody; Mitotic spindle checkpoint kinase antibody; Putative serine/threonine protein kinase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O43683
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 protein (256-577AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Serine/threonine-protein kinase that performs 2 crucial functions during mitosis : it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can reg µLate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1
Research Areas : Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : Bub1 antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog antibody; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) antibody; BUB1 mitotic checkpoint serine/threonine kinase antibody; BUB1; S. cerevisiae; homolog of antibody; BUB1_HUMAN antibody; BUB1A antibody; BUB1L antibody; Budding uninhibited by benzimidazoles 1 (yeast homolog) antibody; Budding uninhibited by benzimidazoles 1 homolog antibody; Budding uninhibited by benzimidazoles 1; S. cerevisiae; homolog of antibody; hBUB1 antibody; Homolog of mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint gene BUB1 antibody; Mitotic checkpoint serine/threonine protein kinase BUB1 antibody; Mitotic checkpoint serine/threonine-protein kinase BUB1 antibody; Mitotic spindle checkpoint kinase antibody; Putative serine/threonine protein kinase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O43683
Immunogen : Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 protein (256-577AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Serine/threonine-protein kinase that performs 2 crucial functions during mitosis : it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can reg µLate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BUB1
Research Areas : Cancer; Cell biology

Volume : 100 µL
Host : Rabbit
Clonality : polyclonal Ab
Isotype : IgG
GeneName : BUB1
GeneID : 699
Uniprot : O43683
Specificity : Bub1 Antibody detects endogenous levels of total Bub1.
Immunogen : A syntheVolumed peptide derived from human Bub1 corresponding to a region within the internal amino acids.
Storage : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Reactivity : Human
Prediction : Rabbit,Dog
Application : WB,ELISA(peptide)
Dilution : WB 1 : 500-1 : 1000, ELISA(peptide) 1 : 20000-1 : 40000
Conj µgate : Unconj µgated
RRID : AB_2837127
An Introduction to Blocking Peptides : A superior strategy for validation of antibody binding is the use of blocking peptides. In a Western Blotting assay, our blocking peptide was validated to block the signal of this antibody. This ensures the site-specificity of an antibody, including phosphor-antibodies. In the case of the phosphor- antibodies, the antibodies can and will only recognize the phosphorylated target protein at the corresponding site, not the non-phosphorylated target protein or target protein phosphorylated at a different site.
Cat# Blocking Peptide : DF4773-BP
Des# Blocking Peptide : Bub1 Blocking peptide
Blocking Peptide Price : $549 CAD

Volume : 50 µg
Clone Number :
Aliases : Beta transducin repeat containing E3 ubiquitin protein ligase antibody; beta TrCP1 antibody; beta-transducin repeat containing antibody; BETA-TRCP antibody; betaTrCP antibody; btrC antibody; bTrCP antibody; bTrCP1 antibody; E3RSIkappaB antibody; F box and WD repeat protein 1B antibody; F box and WD repeats protein beta TrCP antibody; F-box and WD repeats protein beta-TrCP antibody; F-box/WD repeat protein 1A antibody; F-box/WD repeat-containing protein 1A antibody; FBW1A antibody; FBW1A_HUMAN antibody; FBXW1 antibody; FBXW1A antibody; FWD1 antibody; HOS antibody; mKIAA4123 antibody; pIkappaBalpha-E3 receptor subunit antibody; Slimb antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y297
Immunogen : Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Substrate recognition component of a SCF (SKP1-C µL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at \'Lys-21\' and \'Lys-22\'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed : 25704143, PubMed : 25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 FBXO5, PER1 SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation thro µgh a DBB1-C µL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1 IKBKB and TNF. Required for proteolytic processing of GLI3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BTRC
Research Areas : Neuroscience; Cell biology; Microbiology

Volume : 50 µg
Clone Number :
Aliases : Beta transducin repeat containing E3 ubiquitin protein ligase antibody; beta TrCP1 antibody; beta-transducin repeat containing antibody; BETA-TRCP antibody; betaTrCP antibody; btrC antibody; bTrCP antibody; bTrCP1 antibody; E3RSIkappaB antibody; F box and WD repeat protein 1B antibody; F box and WD repeats protein beta TrCP antibody; F-box and WD repeats protein beta-TrCP antibody; F-box/WD repeat protein 1A antibody; F-box/WD repeat-containing protein 1A antibody; FBW1A antibody; FBW1A_HUMAN antibody; FBXW1 antibody; FBXW1A antibody; FWD1 antibody; HOS antibody; mKIAA4123 antibody; pIkappaBalpha-E3 receptor subunit antibody; Slimb antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y297
Immunogen : Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Substrate recognition component of a SCF (SKP1-C µL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at \'Lys-21\' and \'Lys-22\'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed : 25704143, PubMed : 25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 FBXO5, PER1 SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation thro µgh a DBB1-C µL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1 IKBKB and TNF. Required for proteolytic processing of GLI3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BTRC
Research Areas : Neuroscience; Cell biology; Microbiology

Volume : 50 µg
Clone Number :
Aliases : Beta transducin repeat containing E3 ubiquitin protein ligase antibody; beta TrCP1 antibody; beta-transducin repeat containing antibody; BETA-TRCP antibody; betaTrCP antibody; btrC antibody; bTrCP antibody; bTrCP1 antibody; E3RSIkappaB antibody; F box and WD repeat protein 1B antibody; F box and WD repeats protein beta TrCP antibody; F-box and WD repeats protein beta-TrCP antibody; F-box/WD repeat protein 1A antibody; F-box/WD repeat-containing protein 1A antibody; FBW1A antibody; FBW1A_HUMAN antibody; FBXW1 antibody; FBXW1A antibody; FWD1 antibody; HOS antibody; mKIAA4123 antibody; pIkappaBalpha-E3 receptor subunit antibody; Slimb antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y297
Immunogen : Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Substrate recognition component of a SCF (SKP1-C µL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at \'Lys-21\' and \'Lys-22\'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed : 25704143, PubMed : 25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1 FBXO5, PER1 SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation thro µgh a DBB1-C µL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1 IKBKB and TNF. Required for proteolytic processing of GLI3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : BTRC
Research Areas : Neuroscience; Cell biology; Microbiology