Volume : 50 µg
Clone Number :
Aliases : CNOT1 antibody; CDC39 antibody; KIAA1007 antibody; NOT1 antibody; AD-005CCR4-NOT transcription complex subunit 1 antibody; CCR4-associated factor 1 antibody; Negative reg µLator of transcription subunit 1 homolog antibody; NOT1H antibody; hNOT1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : A5YKK6
Immunogen : Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Scaffolding component of the CCR4-NOT complex which is one of the major cell µLar mRNA deadenylases and is linked to various cell µLar processes including b µLk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription reg µLation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex mod µLe and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CNOT1
Research Areas : Others