Volume : 50 µg
Clone Number :
Aliases : C type lectin domain family 4 member E antibody; C type lectin superfamily member 9 antibody; C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9 antibody; C-type lectin domain family 4 member E antibody; C-type lectin superfamily member 9 antibody; CLC4E_HUMAN antibody; CLEC 4E antibody; Clec4e antibody; CLECSF9 antibody; Macrophage inducible C type lectin antibody; Macrophage-inducible C-type lectin antibody; MINCLE antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9 µLY5
Immunogen : Recombinant Human C-type lectin domain family 4 member E protein (41-219AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6\\\'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals thro µgh an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines thro µgh a pathway that depends on SYK, CARD9 and NF-kappa-B.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CLEC4E
Research Areas : Immunology