Volume : 50 µg
Clone Number :
Aliases : BRSS antibody; CDMT antibody; Cyld antibody; CYLD gene antibody; CYLD_HUMAN antibody; CYLD1 antibody; CYLDI antibody; cylindromatosis (turban tumor syndrome) antibody; cylindromatosis 1 antibody; Deubiquitinating enzyme CYLD antibody; EAC antibody; HSPC057 antibody; KIAA0849 antibody; MFT antibody; MFT1 antibody; Probable ubiquitin carboxyl terminal hydrolase CYLD antibody; SBS antibody; TEM antibody; turban tumor syndrome antibody; Ubiquitin carboxyl-terminal hydrolase CYLD antibody; ubiquitin specific peptidase like 2 antibody; ubiquitin thioesterase CYLD antibody; Ubiquitin thiolesterase CYLD antibody; Ubiquitin-specific processing protease CYLD antibody; Ubiquitin-specific-processing protease CYLD antibody; USPL2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9NQC7
Immunogen : Recombinant Human Ubiquitin carboxyl-terminal hydrolase CYLD protein (269-435AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Deubiquitinase that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the reg µLation of pathways leading to NF-kappa-B activation (PubMed : 12917689, PubMed : 12917691). Contributes to the reg µLation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed : 12917690). Negative reg µLator of Wnt signaling (PubMed : 20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tub µLin and stabilization of microtub µLes (PubMed : 19893491). Plays a role in the reg µLation of microtub µLe dynamics, and thereby contributes to the reg µLation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed : 18222923, PubMed : 20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed : 17495026, PubMed : 19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the reg µLation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed : 18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively reg µLates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the reg µLation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear (\'Met-1\'-linked) polyubiquitin chains to reg µLate innate immunity : recruited to the LUBAC complex and, together with OT µLIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stim µLation (PubMed : 26670046, PubMed : 26997266).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CYLD
Research Areas : Others