Volume : 50 µg
Clone Number :
Aliases : Casein Kinase 1 delta antibody; Casein kinase I delta isoform antibody; Casein kinase I isoform delta antibody; CKI delta antibody; CKI-delta antibody; CKId antibody; CKIdelta antibody; CSNK 1D antibody; CSNK1D antibody; HCKID antibody; KC1D_HUMAN antibody; Protein kinase CK1 delta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P48730
Immunogen : Recombinant Human Casein kinase I isoform delta protein (152-398AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Essential serine/threonine-protein kinase that reg µLates diverse cell µLar growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1 MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1 AIB1/NCOA3, DNMT1 PKD2, YAP1 PER1 and PER2. Central component of the circadian clock. In balance with PP1 determines the circadian period length thro µgh the reg µLation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stim µLates their activity and coactivation. Phosphorylation of DVL2 and DVL3 reg µLates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-reg µLation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May reg µLate the formation of the mitotic spindle apparatus in extravillous trophoblast. Mod µLates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Reg µLates fast synaptic transmission mediated by glutamate.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSNK1D
Research Areas : Neuroscience; Cell biology; Stem cells